Brian Thomas Littrell was born on February 20, 1975, in Lexington, Kentucky, United States. His parents are named Harold Baker Littrell, jr and his mother Jackie Fox, he has an older brother Harold Baker Jr. 

He was born with a heart defect that took him to the hospital several times with severe living conditions. A the five year old due to a bacterial infection had to be hospitalized for two months. An open heart surgery in 1998 closed the hole in his heart, the operation was urgent but he moved her twice because of the tour he had at the time, but thanks to the insistence of his girlfriend at the time, now his wife, Leighanne, it was that you agreed to schedule the operation. 
After that, he founded "Healthy Heart Club" for children, a non-profit organization that helps children with heart disease with medical, financial and practical help.